Volume 101, Issue 11 p. 1388-1395

The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study

Karin S. Coyne,

Karin S. Coyne

United BioSource Corporation, Bethesda, MD, University of North Carolina, Chapel Hill, NC,

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Chris C. Sexton,

Chris C. Sexton

United BioSource Corporation, Bethesda, MD, University of North Carolina, Chapel Hill, NC,

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Debra E. Irwin,

Debra E. Irwin

United BioSource Corporation, Bethesda, MD, University of North Carolina, Chapel Hill, NC,

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Zoe S. Kopp,

Zoe S. Kopp

Pfizer Incorporated, New York, NY, USA,

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Con J. Kelleher,

Con J. Kelleher

St Thomas’ Hospital, London, UK, and

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Ian Milsom,

Ian Milsom

Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Göteborg, Sweden

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Karin S. Coyne,

Karin S. Coyne

United BioSource Corporation, Bethesda, MD, University of North Carolina, Chapel Hill, NC,

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Chris C. Sexton,

Chris C. Sexton

United BioSource Corporation, Bethesda, MD, University of North Carolina, Chapel Hill, NC,

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Debra E. Irwin,

Debra E. Irwin

United BioSource Corporation, Bethesda, MD, University of North Carolina, Chapel Hill, NC,

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Zoe S. Kopp,

Zoe S. Kopp

Pfizer Incorporated, New York, NY, USA,

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Con J. Kelleher,

Con J. Kelleher

St Thomas’ Hospital, London, UK, and

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Ian Milsom,

Ian Milsom

Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Göteborg, Sweden

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First published: 01 May 2008

https://doi.org/10.1111/j.1464-410X.2008.07601.x

Citations: 632

Karin Coyne, Senior Research Leader, United BioSource Corporation, 7101 Wisconsin Ave, Suite 600, Bethesda, MD 20814, USA.
e-mail: [email protected]

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Abstract

OBJECTIVES

To examine the effect overactive bladder (OAB) and other lower urinary tract symptoms (LUTS) on health-related quality of life (HRQoL) in a population sample, as OAB often occurs in conjunction with many other LUTS.

SUBJECTS AND METHODS

A nested case-control analysis was performed on men and women with (cases) and without (controls) OAB, from the EPIC study. OAB was assessed using 2002 International Continence Society definitions. Based on their responses to questions about LUTS, cases were classified into five groups; continent OAB, OAB with incontinence, OAB + postmicturition, OAB + voiding, and OAB + postmicturition + voiding. Both cases and controls were asked questions about symptom bother (OAB-q), generic QoL (EQ-5D), work productivity (Work Productivity and Activity Impairment, WPAI), depressive symptoms (Center for Epidemiologic Studies Depression Scale), sexual satisfaction, and erectile dysfunction (men only) using the Massachusetts Male Aging Study. Cases answered additional condition-specific questions HRQoL (OAB-q short form), Patient Perception of Bladder Condition and work productivity related to a specific health problem (WPAI-SHP). General linear models were used to evaluate group differences.

RESULTS

Of the EPIC participants, 1434 identified OAB cases were matched by age, gender and country, with 1434 participants designated as controls. Cases and controls were primarily Caucasian (96.2% and 96.7%, respectively), and most (65%) were female; the mean age was 53.8 and 53.7 years, respectively. Comorbid conditions differed significantly by case/control status, with cases reporting significantly greater rates of chronic constipation, asthma, diabetes, high blood pressure, bladder or prostate cancer, neurological conditions and depression. There were significant differences between the cases and controls in all reported LUTS. The OAB + postmicturition + voiding group reported significantly greater symptom bother, worse HRQoL, higher rates of depression and decreased enjoyment of sexual activity, than the other subgroups.

CONCLUSION

OAB has a substantial, multidimensional impact on patients; OAB with additional LUTS has a greater impact. The diagnosis and treatment of OAB should be considered in conjunction with other LUTS, to maximize treatment options and optimize patient outcomes.

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Citing Literature

Volume101, Issue11

June 2008

Pages 1388-1395

The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study

Abstract

OBJECTIVES

SUBJECTS AND METHODS

RESULTS

CONCLUSION

REFERENCES

Citing Literature

References

Information

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The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study

Abstract

OBJECTIVES

SUBJECTS AND METHODS

RESULTS

CONCLUSION

REFERENCES

Citing Literature

References

Related

Information